INDIANAPOLIS -- The Indianapolis Colts had 12 months to reflect on how Houston got its first win on its home turf -- and the AFC South title last season.They may have let it slip away again Sunday.After spending the past month fighting their way back into the division chase and a potential playoff spot, the Colts took a major step backward Sunday with a 22-17 loss to the Texans.Its hard to sort of digest big implications and I think as players, we dont, Andrew Luck said.We know we have to go out and take care of our business. Theres a little bit of hoping involved, but we still have to take care of business.The consequence of losing a mid-December game in this series is well-documented.Over the past four years, the winner has won the AFC South title. The loser, each of the past three years, didnt make the postseason.It could happen again.Houston and Tennessee are tied for the division lead at 7-6 but with a sweep over the Titans and the first season sweep of Indianapolis (6-7) in franchise history, the Texans have a clear path to defending their AFC South title.The Colts, meanwhile, must win and hope that the Texans, Titans and perhaps other teams stumble over the final three weeks of the season.While the prospects look daunting with their next two games at Minnesota and Oakland, coach Chuck Pagano insisted it wasnt over and urged his players not to lose faith.I dont have a crystal ball. All we can do is, like we always do, get over this in a hurry, he said. There are so many things that can happen, we all see it. We all know it.What the loss did, though, is probably force the Colts into needing help to avoid missing the playoffs in consecutive seasons for the first time since 1997 and 1998.And the growing injury list wont help, either.Indy started the game without linebacker Robert Mathis (biceps), safety Clayton Geathers (neck), cornerback Patrick Robinson (groin) and right guard Denzelle Good (concussion). Left guard Jack Mewhort (left knee) and receiver Donte Moncrief (hamstring) couldnt finish the game.Center Ryan Kelly also left the game briefly, leaving the Colts temporarily without three of their five offensive line starters until Kelly returned.So with three key games still on the schedule, Indianapolis has no choice but to play through the injuries and hope for the best -- or suffer the same fate they did after last seasons December loss to the Texans.We blew it, cornerback Darius Butler said. At home, having the game right there, but they outplayed us today. 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The lower tier of the School End of Queens Park Rangers Loftus Road was packed solid with a very festive-sounding Chelsea choral section in this particular part of South Africa Road London, W12.COLUMBIA, Mo. -- Drew Lock completed 22 of 37 passes for 294 yards and two touchdowns as Missouri defeated Vanderbilt 26-17 on Saturday.It marks Missouris first Southeastern Conference victory since Locks starting debut, a 24-10 victory over South Carolina on Oct. 3, 2015.Each team opened with a three-and-out before Damarea Crocketts 6-yard touchdown run gave Missouri (3-7, 1-5) a lead it would never relinquish. Crockett had 20 carries for 154 yards and the touchdown.JMon Moore caught eight passes for 138 yards and two touchdowns, including an 82-yard score with 9:50 remaining in the second quarter, and Johnathon Johnson added four catches for 73 yards.Kyle Shurmur was 17 of 29 for 252 yards and two interceptions, one of which Missouri cornerback Aarion Penton returned 19 yards for a touchdown, the second of his career.C.J. Duncan caught five passes for 89 yards and Caleb Scott had three catches for 63 yards.Darius Sims rushed seven times for 86 yards, Khari Blasingame had 14 carries for 64 yards and a touchdown, and Ralph Webb added 11 carries for 34 yards and a touchdown.Missouri gained 481 yards despite a 13-minute differential in time of possession. Its the Tigers highest yarrdage total in SEC play since Nov.dddddddddddd 15, 2014 when they gained 587 yards en route to a 34-27 victory over Texas A&M.Vanderbilt (4-6, 1-5) punted three times in the fourth quarter and was held to -14 yards.TAKEAWAYSVanderbilt: The Commodores struggled on third down, converting on just 3 of 14 attempts, while also failing their only fourth down conversion attempt. Missouri converted 10 of 19 third down attempts, including 7 of 11 in the second half.Missouri: The Tigers brought the pressure defensively, racking up six sacks and nine tackles for losses. Charles Harris made eight tackles -three of them for losses -- 2 1/2 sacks and a forced fumble, and Marcell Frazier added 1 1/2. Vanderbilt amassed 411 yards, the lowest opponent yardage total Missouris defense has allowed in six games.UP NEXTVanderbilt: The Commodores host Ole Miss (4-5, 1-4 SEC) next Saturday. The Rebels defeated Vanderbilt 27-16 last season in Oxford.Missouri: The Tigers visit Tennessee (7-3, 3-3 SEC) next Saturday. The Volunteers defeated Missouri 19-8 last season in Columbia. ' ' '